| Gene Information | |
|---|---|
| Gene Name | CAVIN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | Caveolae-associated protein 4 (Muscle-related coiled-coil protein) (Muscle-restricted coiled-coil protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000170681 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q5BKX8 |
| Gene Card | CAVIN4 |
| Uniprot ID | Q5BKX8 |
| Pfam | PF15237 |
| In ASD | no |
| Allosteric Prediction | no (-1.189187422) |
| Ortholog in Animals | Alpaca_ CAVIN4 ( ortholog_one2one ) Dog_ CAVIN4 ( ortholog_one2one ) GuineaPig_ CAVIN4 ( ortholog_one2one ) Mouse_ Cavin4 ( ortholog_one2one ) Pig_ CAVIN4 ( ortholog_one2one ) Rat_ Cavin4 ( ortholog_one2one ) Rabbit_ CAVIN4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CAVIN2, CAVIN3, CAVIN1 |
| Tissue | heart, skeletal.muscle, artery, tongue |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:A2AMM0}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:A2AMM0}. Membrane, caveola {ECO:0000269|PubMed:19525939}. Cell membrane {ECO:0000269|PubMed:26497963}. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000250|UniProtKB:A2AMM0}. |
| Mouse PG classification | NA |
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