| Gene Information | |
|---|---|
| Gene Name | FBN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2809 |
| Protein Names | Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide] |
| Target Name | fibrillin-3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000142449 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | FBN3 |
| Uniprot ID | Q75N90 |
| Pfam | PF12662; PF07645; PF18193; PF12661; PF00683 |
| In ASD | no |
| Allosteric Prediction | no (-0.578483617) |
| Ortholog in Animals | Alpaca_ FBN3 ( ortholog_one2one ) Dog_ FBN3 ( ortholog_one2one ) Macaque_ FBN3 ( ortholog_one2one ) Pig_ FBN3 ( ortholog_one2one ) Rabbit_ FBN3 ( ortholog_one2one ) |
| Ohnologs | FBN2, FBN1 |
| Paralogs | FBN1, FBN2 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in connective tissues such as skeletal muscle, tendon, skin, perichondrium and periosteum. Highly expressed in fetal lung, brain, kidney. Expressed at low level in prostate, testis, mammary gland, uterus, ovary, placenta, bladder, adrenal gland, thyroid, fetal thymus, fetal liver, liver, fetal heart and heart. {ECO:0000269|PubMed:14962672}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3813773 rs7246376 rs35999680 rs35277492 rs36124795 rs4804271 rs35025963 rs35579498 rs34684510 rs4804063 rs4804063 rs12975322 rs17160194 rs33967815 rs3829817 rs10404519 rs12150963 rs12608849 rs12608849 rs7245558 rs7245429 rs34167077 rs17202741 rs17160151 rs3848570 rs35477781 rs35318692 rs7257948 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14962672}. |
| Mouse PG classification | NA |
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