Gene Information

Gene Information
Gene Name	FBN
Organism	Homo sapiens (Human)
Gene Length	2871
Protein Names	Fibrillin-1 [Cleaved into: Asprosin]
Target Name	NA
Target Type	NA
Gene Age	NA
Evolutionary Stage	NA
AlphaFoldDB	NA
Gene Card	FBN1
Uniprot ID	P35555
Pfam	PF12662; PF12947; PF07645; PF18193; PF00683
In ASD	no
Allosteric Prediction	NA
Ortholog in Animals	NA
Ohnologs	NA
Paralogs	NA
Tissue	NA
Tissue Specificity	NA
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1APJ (NMR - ) 1EMN (NMR - ) 1EMO (NMR - ) 1LMJ (NMR - ) 1UZJ (X-ray 2.25A ) 1UZK (X-ray 1.35A ) 1UZP (X-ray 1.78A ) 1UZQ (X-ray 2.40A ) 2M74 (NMR - ) 2W86 (X-ray 1.80A ) 5MS9 (NMR - )
DBSNP	rs201309310 rs25397 rs2044669685 rs25403 rs1303389437 rs113604459 rs111764111 rs112660651 rs397515782 rs137854467 rs397515794 rs1566935524 rs1566935517 rs363850 rs1555405041 rs1057521103 rs1057518973 rs749490298 rs363852 rs363853 rs113695103 rs794728162 rs193922224 rs774754863 rs1555401676 rs137854480 rs12324002 rs363855 rs1555400595 rs139058991 rs4775765 rs1555400378 rs794728326 rs1555400373 rs1555400371 rs587782944 rs1156747241 rs1555400288 rs730880099 rs137854462 rs1064794283 rs1555400049 rs1555399974 rs1555399963 rs1555399959 rs2043732180 rs1555399954 rs1555399944 rs1060501017 rs1566914030 rs727503057 rs1566914005 rs1555399816 rs2043696418 rs1060501086 rs1555399766 rs140603 rs1555399761 rs2043684108 rs137854463 rs1555399381 rs794728187 rs1555399372 rs1064794282 rs1555399273 rs397515766 rs1555399271 rs193922188 rs1555399210 rs1555399206 rs397515770 rs397515775 rs1555399165 rs2043595650 rs794728194 rs794728195 rs1555399149 rs1060501021 rs1057523406 rs1555398995 rs1555398989 rs1555398835 rs397514558 rs140954477 rs747713929 rs137854477 rs794728199 rs140592 rs140593 rs111801777 rs137854481 rs1555398681 rs137854472 rs730880100 rs1555398673 rs2229324 rs1597564258 rs1060501040 rs397515786 rs794728202 rs1293095681 rs137854478 rs137854465 rs1555398645 rs1555398633 rs1555398625 rs140597 rs137854470 rs137854468 rs137854482 rs137854473 rs137854456 rs397515791 rs140598 rs140599 rs794728204 rs1597562926 rs137854475 rs775417975 rs1555398512 rs1555398394 rs137854469 rs137854471 rs137854458 rs137854474 rs140647 rs1555398173 rs1597558920 rs753648789 rs397515798 rs1555397718 rs763449629 rs193922203 rs1420739555 rs1555397646 rs2043386794 rs201273753 rs1555397546 rs112375043 rs1555397540 rs61730054 rs730880101 rs193922205 rs112723282 rs111401431 rs267606800 rs267606800 rs267606799 rs776625874 rs267606801 rs1555397024 rs267606798 rs1597546984 rs137854459 rs140627 rs140627 rs387906625 rs387906622 rs387906626 rs1064797059 rs387906624 rs1131691804 rs1131692052 rs387906623 rs1555396428 rs1555396427 rs886038848 rs1597540854 rs2043240309 rs761857514 rs1597537935 rs1555396213 rs2043210015 rs111929350 rs111929350 rs755430984 rs397515823 rs1555396186 rs1597535300 rs1555395984 rs112728248 rs2043178850 rs1597533706 rs1057521101 rs878853686 rs794728237 rs1060501087 rs1304811982 rs794728333 rs1555395826 rs2043162224 rs587782947 rs794728240 rs111239111 rs1555395665 rs1555395663 rs1555395659 rs727504642 rs1085307531 rs363802 rs363804 rs363805 rs794728245 rs200816828 rs363815 rs1131691467 rs363816 rs112989722 rs794728334 rs794728335 rs137854461 rs794728251 rs756219617 rs794728252 rs363821 rs910656654 rs886038976 rs113543334 rs137854460 rs1555394919 rs1060501054 rs112084407 rs112836174 rs1057520617 rs886039047 rs193922228 rs754270535 rs363835 rs765205164 rs2042998789 rs137854457 rs111588631 rs363831 rs794728262 rs1555394580 rs397515845 rs1131691479 rs1555394435 rs137854464 rs1566892757 rs1555394397 rs1555394398 rs869025415 rs1057520728 rs363810 rs794728160 rs794728272 rs2042946390 rs763759308 rs794728336 rs113544411 rs397515854 rs369294972 rs1566891654 rs886038786 rs2042934926 rs1555394149 rs727503054 rs111984349 rs141133182 rs193922239 rs1555393863 rs1057521100 rs794728283 rs759494825 rs61746008 rs1409931715 rs869025417 rs113722038
Subcellular location [CC]	Secreted {ECO:0000269\|PubMed:24982166, ECO:0000269\|PubMed:34411563}. Note=Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin (PubMed:24982166). {ECO:0000269\|PubMed:24982166}.; [Fibrillin-1]: Secreted, extracellular space, extracellular matrix {ECO:0000269\|PubMed:11461921, ECO:0000269\|PubMed:24982166}.; [Asprosin]: Secreted {ECO:0000269\|PubMed:27087445}. Note=Secreted by white adipose tissue and circulates in the plasma. {ECO:0000269\|PubMed:27087445}.
Mouse PG classification	NA
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