| Gene Information | |
|---|---|
| Gene Name | FBLP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8WUP2 |
| Gene Card | FBLIM1 |
| Uniprot ID | Q8WUP2 |
| Pfam | PF00412 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269|PubMed:12496242}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K9U (NMR - ) 2W0P (X-ray 1.90A ) 4P3W (X-ray 2.00A ) |
| DBSNP | rs34375304 rs10927851 |
| Subcellular location [CC] | Cell junction, focal adhesion {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites (PubMed:12679033, PubMed:18829455). Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2 (PubMed:12679033). Isoform 2 is localized at actin stress fibers (PubMed:12496242). {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. |
| Mouse PG classification | NA |
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