| Gene Information | |
|---|---|
| Gene Name | U2AF1L4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 220 |
| Protein Names | Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000161265 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WU68 |
| Gene Card | U2AF1L4 |
| Uniprot ID | Q8WU68 |
| Pfam | PF00076; PF00642 |
| In ASD | no |
| Allosteric Prediction | no (-0.765951387) |
| Ortholog in Animals | Alpaca_ U2AF1L4 ( ortholog_one2one ) Dog_ U2AF1L4 ( ortholog_one2one ) Macaque_ U2AF1L4 ( ortholog_one2one ) Mouse_ U2af1l4 ( ortholog_one2one ) Pig_ U2AF1L4 ( ortholog_one2one ) Rat_ U2af1l4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | U2AF1, ZRSR2 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:17312947}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo-cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9}. |
| Mouse PG classification | NA |
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