| Gene Information | |
|---|---|
| Gene Name | FBL |
| Organism | Homo sapiens (Human) |
| Gene Length | 321 |
| Protein Names | rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000105202 ) 3 ( ENSG00000280548 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P22087 |
| Gene Card | FBL |
| Uniprot ID | P22087 |
| Pfam | PF01269 |
| In ASD | no |
| Allosteric Prediction | no (-1.000110767) |
| Ortholog in Animals | Alpaca_ FBL ( ortholog_one2many ) Dog_ FBL ( ortholog_one2one ) GuineaPig_ FBL ( ortholog_one2one ) Macaque_ FBL ( ortholog_one2one ) Mouse_ Fbl ( ortholog_one2one ) Pig_ FBL ( ortholog_one2one ) Rat_ Fbl ( ortholog_one2one ) Rabbit_ FBL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FBLL1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001243(Rat);0.091185(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IPX (X-ray 1.82A ) 7MQ8 (EM 3.60A ) 7MQ9 (EM 3.87A ) 7MQA (EM 2.70A ) 7SE6 (X-ray 1.99A ) 7SE7 (X-ray 1.75A ) 7SE8 (X-ray 1.75A ) 7SE9 (X-ray 1.75A ) 7SEA (X-ray 1.91A ) 7SEB (X-ray 1.81A ) 7SEC (X-ray 1.90A ) 7SED (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:14583623, ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:2026646, ECO:0000269|PubMed:2414294, ECO:0000269|PubMed:24352239}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P35550}. Note=Fibrillar region of the nucleolus. |
| Mouse PG classification | NA |
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