| Gene Information | |
|---|---|
| Gene Name | FBH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1043 |
| Protein Names | F-box DNA helicase 1 (hFBH1) (EC 3.6.4.12) (F-box only protein 18) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134452 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8NFZ0 |
| Gene Card | FBH1 |
| Uniprot ID | Q8NFZ0 |
| Pfam | PF12937; PF13361 |
| In ASD | no |
| Allosteric Prediction | no (-0.826318163) |
| Ortholog in Animals | Alpaca_ FBH1 ( ortholog_one2one ) Dog_ FBH1 ( ortholog_one2one ) GuineaPig_ FBH1 ( ortholog_one2one ) Macaque_ FBH1 ( ortholog_one2one ) Mouse_ Fbh1 ( ortholog_one2one ) Pig_ FBH1 ( ortholog_one2one ) Rat_ Fbh1 ( ortholog_one2one ) Rabbit_ FBH1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.418684(Rat);0.110373(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23677613}. Chromosome {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23677613}. Note=Accumulates at sites of DNA damage or replication stress (PubMed:19736316, PubMed:23677613). PCNA is required for localization to DNA damage sites (PubMed:23677613). Localizes to the nucleoplasm in absence of DNA damage (PubMed:23677613). {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23677613}. |
| Mouse PG classification | NA |
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