| Gene Information | |
|---|---|
| Gene Name | FAT4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4981 |
| Protein Names | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000196159 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | NA |
| Gene Card | FAT4 |
| Uniprot ID | Q6V0I7 |
| Pfam | PF00028; PF07645; PF12661; PF02210 |
| In ASD | no |
| Allosteric Prediction | no (-1.238690208) |
| Ortholog in Animals | Alpaca_ FAT4 ( ortholog_one2one ) Dog_ FAT4 ( ortholog_one2one ) GuineaPig_ FAT4 ( ortholog_one2one ) Macaque_ FAT4 ( ortholog_one2one ) Mouse_ Fat4 ( ortholog_one2one ) Pig_ FAT4 ( ortholog_one2one ) Rat_ Fat4 ( ortholog_one2one ) Rabbit_ FAT4 ( ortholog_one2one ) |
| Ohnologs | CDH23 |
| Paralogs | CELSR3, FAT2, FAT1, CELSR1, FAT3, CELSR2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. {ECO:0000269|PubMed:15003449, ECO:0000269|PubMed:16865240}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6847454 rs1039808 rs398122955 rs1485569217 rs1567047 rs17009684 rs12650153 rs398122953 rs199682210 rs11942361 rs398122954 rs1014867 rs17009858 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In the kidney, localizes to primary cilia. {ECO:0000250}. |
| Mouse PG classification | NA |
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