| Gene Information | |
|---|---|
| Gene Name | FAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4588 |
| Protein Names | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000083857 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | FAT1 |
| Uniprot ID | Q14517 |
| Pfam | PF00028; PF00008; PF02210 |
| In ASD | no |
| Allosteric Prediction | yes (0.380950329) |
| Ortholog in Animals | Alpaca_ FAT1 ( ortholog_one2one ) Dog_ FAT1 ( ortholog_one2one ) GuineaPig_ FAT1 ( ortholog_one2one ) Macaque_ FAT1 ( ortholog_one2one ) Mouse_ Fat1 ( ortholog_one2one ) Rat_ Fat1 ( ortholog_one2one ) Rabbit_ FAT1 ( ortholog_one2one ) |
| Ohnologs | FAT2, FAT3 |
| Paralogs | CELSR3, FAT2, CELSR1, FAT4, FAT3, CELSR2 |
| Tissue | NA |
| Tissue Specificity | Expressed in many epithelial and some endothelial and smooth muscle cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3733415 rs1373737710 rs555992573 rs1383300308 rs874111 rs753226094 rs2304867 rs6836935 rs748622474 rs373241719 rs11731738 rs1409256573 |
| Subcellular location [CC] | [Protocadherin Fat 1]: Cell membrane {ECO:0000269|PubMed:15922730}; Single-pass type I membrane protein {ECO:0000269|PubMed:15922730}.; [Protocadherin Fat 1, nuclear form]: Nucleus {ECO:0000269|PubMed:15922730}. |
| Mouse PG classification | NA |
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