Gene Information
Gene NameFASN
OrganismHomo sapiens (Human)
Gene Length2511
Protein NamesFatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]
Target Namefatty acid synthase
Target TypeSuccessful target
Gene Age950 ( ENSG00000169710 )
Evolutionary StageEuk+Bac
AlphaFoldDBP49327
Gene CardFASN
Uniprot IDP49327
PfamPF00698; PF00107; PF16197; PF00109; PF02801; PF08659; PF08242; PF00550; PF14765; PF00975
In ASDyes
Allosteric Predictionyes (1.000433733)
Ortholog in AnimalsAlpaca_ FASN ( ortholog_one2one )
Dog_ FASN ( ortholog_one2one )
GuineaPig_ FASN ( ortholog_one2one )
Macaque_ FASN ( ortholog_one2one )
Mouse_ Fasn ( ortholog_one2one )
Pig_ FASN ( ortholog_one2one )
Rat_ Fasn ( ortholog_one2one )
OhnologsNA
ParalogsOXSM
TissueNA
Tissue SpecificityUbiquitous. Prominent expression in brain, lung, liver and mammary gland. {ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:7595075}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1XKT  (X-ray  2.60A  )  2CG5  (X-ray  2.70A  )  2JFD  (X-ray  2.81A  )  2JFK  (X-ray  2.40A  )  2PX6  (X-ray  2.30A  )  3HHD  (X-ray  2.15A  )  3TJM  (X-ray  1.48A  )  4PIV  (X-ray  2.30A  )  4W82  (X-ray  1.70A  )  4W9N  (X-ray  1.84A  )  4Z49  (X-ray  1.70A  )  5C37  (X-ray  2.30A  )  6NNA  (X-ray  2.26A  )  7MHD  (X-ray  2.03A  )  7MHE  (X-ray  2.80A  ) 
DBSNP rs113931914  rs2228305  rs561903908  rs2228307 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Mouse PG classificationNA
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