| Gene Information | |
|---|---|
| Gene Name | CCR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194) |
| Target Name | c-c chemokine receptor type 4 |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000183813 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51679 |
| Gene Card | CCR4 |
| Uniprot ID | P51679 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000245097) |
| Ortholog in Animals | Alpaca_ CCR4 ( ortholog_one2one ) Dog_ CCR4 ( ortholog_one2one ) GuineaPig_ Ccr4 ( ortholog_one2one ) Macaque_ CCR4 ( ortholog_one2one ) Mouse_ Ccr4 ( ortholog_one2one ) Pig_ CCR4 ( ortholog_one2one ) Rat_ Ccr4 ( ortholog_one2one ) |
| Ohnologs | CCR6, LPAR4, CMKLR1, CCR10, CXCR3, CXCR4, ACKR3, AGTR1, CXCR1, CXCR2 |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, GALR2, XCR1, RGR, ACKR3, CCRL2, CCR1, CCR2, CCR5, CCR3, CCR8, CX3CR1, ACKR2 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. {ECO:0000269|PubMed:10754297}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs753825374 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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