| Gene Information | |
|---|---|
| Gene Name | FAS |
| Organism | Homo sapiens (Human) |
| Gene Length | 335 |
| Protein Names | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) |
| Target Name | apoptosis mediating surface antigen fas |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000026103 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P25445 |
| Gene Card | FAS |
| Uniprot ID | P25445 |
| Pfam | PF00531; PF00020 |
| In ASD | no |
| Allosteric Prediction | yes (1.190496079) |
| Ortholog in Animals | Alpaca_ FAS ( ortholog_one2one ) Dog_ FAS ( ortholog_one2one ) GuineaPig_ FAS ( ortholog_one2one ) Mouse_ Fas ( ortholog_one2one ) Pig_ FAS ( ortholog_one2one ) Rat_ Fas ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. {ECO:0000269|PubMed:7575433}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DDF (NMR - ) 2NA7 (NMR - ) 3EWT (X-ray 2.40A ) 3EZQ (X-ray 2.73A ) 3THM (X-ray 2.10A ) 3TJE (X-ray 1.93A ) |
| DBSNP | rs3218619 rs606231364 rs121913083 rs121913078 rs3218614 rs121913084 rs758835365 rs28362322 rs121913079 rs201072885 rs121913076 rs121913080 rs121913082 rs28929498 rs121913086 rs121913081 rs3218611 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1713127, ECO:0000269|PubMed:25301068}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:25301068}.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted. |
| Mouse PG classification | HPG |
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