| Gene Information | |
|---|---|
| Gene Name | OPALIN |
| Organism | Homo sapiens (Human) |
| Gene Length | 141 |
| Protein Names | Opalin (Oligodendrocytic myelin paranodal and inner loop protein) (Transmembrane protein 10) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000197430 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96PE5 |
| Gene Card | OPALIN |
| Uniprot ID | Q96PE5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.004344419) |
| Ortholog in Animals | Alpaca_ OPALIN ( ortholog_one2one ) Dog_ OPALIN ( ortholog_one2one ) Macaque_ OPALIN ( ortholog_one2one ) Mouse_ Opalin ( ortholog_one2one ) Pig_ OPALIN ( ortholog_one2one ) Rat_ Opalin ( ortholog_one2one ) Rabbit_ OPALIN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | brain, cerebral.cortex, amygdala, caudate.nucleus, hippocampus, hypothalamus, putamen, substantia.nigra |
| Tissue Specificity | Brain specific; expressed in oligodendrocytes (PubMed:11814680, PubMed:30837646). Expressed in oligodendrocytes in remyelinating multiple sclerosis plaques (PubMed:30837646). {ECO:0000269|PubMed:11814680, ECO:0000269|PubMed:30837646}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q7M750}; Single-pass type I membrane protein {ECO:0000255}. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. Enriched in the leading edge of extending processes. {ECO:0000250|UniProtKB:Q7M750}. |
| Mouse PG classification | NA |
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