| Gene Information | |
|---|---|
| Gene Name | FARS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 451 |
| Protein Names | Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS) |
| Target Name | phenylalanine--trna ligase, mitochondrial |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000145982 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O95363 |
| Gene Card | FARS2 |
| Uniprot ID | O95363 |
| Pfam | PF03147; PF01409 |
| In ASD | no |
| Allosteric Prediction | no (-1.054990839) |
| Ortholog in Animals | Alpaca_ FARS2 ( ortholog_one2one ) Dog_ FARS2 ( ortholog_one2one ) GuineaPig_ FARS2 ( ortholog_one2one ) Macaque_ FARS2 ( ortholog_one2one ) Mouse_ Fars2 ( ortholog_one2one ) Pig_ FARS2 ( ortholog_one2one ) Rat_ Fars2 ( ortholog_one2one ) Rabbit_ FARS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FARSA, FDXACB1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3CMQ (X-ray 2.20A ) 3HFV (X-ray 2.60A ) 3TEG (X-ray 2.20A ) 3TUP (X-ray 3.05A ) 5MGH (X-ray 1.87A ) 5MGU (X-ray 1.89A ) 5MGV (X-ray 2.05A ) 5MGW (X-ray 1.46A ) |
| DBSNP | rs34382405 rs145555213 rs397514610 rs11243011 rs397514611 rs397514612 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000250|UniProtKB:Q6AYQ3}. Mitochondrion {ECO:0000250|UniProtKB:Q6AYQ3}. |
| Mouse PG classification | NA |
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