| Gene Information | |
|---|---|
| Gene Name | FAN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1017 |
| Protein Names | Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000198690 ) 3 ( ENSG00000276787 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y2M0 |
| Gene Card | FAN1 |
| Uniprot ID | Q9Y2M0 |
| Pfam | PF08774 |
| In ASD | no |
| Allosteric Prediction | no (-0.999902862) |
| Ortholog in Animals | Alpaca_ FAN1 ( ortholog_one2one ) Dog_ FAN1 ( ortholog_one2one ) GuineaPig_ FAN1 ( ortholog_one2one ) Macaque_ FAN1 ( ortholog_one2one ) Mouse_ Fan1 ( ortholog_one2one ) Pig_ FAN1 ( ortholog_one2one ) Rat_ Fan1 ( ortholog_one2one ) Rabbit_ FAN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4REA (X-ray 3.81A ) 4REB (X-ray 4.20A ) 4REC (X-ray 2.20A ) 4RI8 (X-ray 2.90A ) 4RI9 (X-ray 2.90A ) 4RIA (X-ray 3.00A ) 4RIB (X-ray 3.25A ) 4RIC (X-ray 2.80A ) 4RID (X-ray 3.30A ) 4RY3 (X-ray 2.80A ) |
| DBSNP | rs4779794 rs1270571213 rs751703979 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:20935496}. Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ4-type zinc finger (PubMed:20935496). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20935496}. |
| Mouse PG classification | HPG |
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