| Gene Information | |
|---|---|
| Gene Name | ALPP |
| Organism | Homo sapiens (Human) |
| Gene Length | 535 |
| Protein Names | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) |
| Target Name | alkaline phosphatase, placental type |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000163283 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P05187 |
| Gene Card | ALPP |
| Uniprot ID | P05187 |
| Pfam | PF00245 |
| In ASD | no |
| Allosteric Prediction | yes (0.371227036) |
| Ortholog in Animals | Alpaca_ ALPP ( ortholog_one2one ) Dog_ ALPI ( ortholog_one2many ) Mouse_ Alppl2 ( ortholog_many2many ) Mouse_ Alpi ( ortholog_many2many ) Mouse_ Akp3 ( ortholog_many2many ) Rat_ Alpi ( ortholog_many2many ) Rat_ Alpg ( ortholog_many2many ) Rat_ Akp3 ( ortholog_many2many ) Rat_ Alpp ( ortholog_many2many ) |
| Ohnologs | ALPL |
| Paralogs | ALPG, ALPI, ALPL |
| Tissue | placenta |
| Tissue Specificity | Detected in placenta (at protein level). {ECO:0000269|PubMed:20693656}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EW2 (X-ray 1.82A ) 1ZEB (X-ray 1.90A ) 1ZED (X-ray 1.57A ) 1ZEF (X-ray 1.90A ) 2GLQ (X-ray 1.60A ) 3MK0 (X-ray 1.90A ) 3MK1 (X-ray 1.57A ) 3MK2 (X-ray 1.89A ) |
| DBSNP | rs1130335 rs13026692 rs1048988 rs2853378 rs1048994 |
| Subcellular location [CC] | Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1730777, ECO:0000269|PubMed:2153284}. |
| Mouse PG classification | NA |
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