| Gene Information | |
|---|---|
| Gene Name | CLCNKA |
| Organism | Homo sapiens (Human) |
| Gene Length | 687 |
| Protein Names | Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1) |
| Target Name | chloride channel protein clc-ka |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000186510 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P51800 |
| Gene Card | CLCNKA |
| Uniprot ID | P51800 |
| Pfam | PF00571; PF00654 |
| In ASD | yes |
| Allosteric Prediction | yes (0.547812454) |
| Ortholog in Animals | Alpaca_ CLCNKA ( ortholog_one2one ) Mouse_ Clcnkb ( ortholog_many2many ) Mouse_ Clcnka ( ortholog_many2many ) Rat_ Clcnka ( ortholog_many2many ) Rat_ Clcnkb ( ortholog_many2many ) |
| Ohnologs | CLCN2, CLCN1 |
| Paralogs | CLCNKB, CLCN6, CLCN3, CLCN5, CLCN1, CLCN7, CLCN4, CLCN2 |
| Tissue | kidney, cortex.of.kidney, pituitary.gland, thyroid |
| Tissue Specificity | Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins. {ECO:0000269|PubMed:11734858}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2PFI (X-ray 1.60A ) |
| DBSNP | rs9442189 rs35932996 rs17855678 rs121909137 rs10927887 rs12126269 rs79751787 rs1805152 rs12140223 rs12746751 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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