Gene Information
Gene NameDNAJB2
OrganismHomo sapiens (Human)
Gene Length324
Protein NamesDnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000135924 )
Evolutionary StageCellular_organisms
AlphaFoldDBP25686
Gene CardDNAJB2
Uniprot IDP25686
PfamPF00226
In ASDno
Allosteric Predictionno (-0.373329697)
Ortholog in AnimalsAlpaca_ DNAJB2 ( ortholog_one2one )
Dog_ DNAJB2 ( ortholog_one2one )
GuineaPig_ DNAJB2 ( ortholog_one2one )
Macaque_ DNAJB2 ( ortholog_one2one )
Mouse_ Dnajb2 ( ortholog_one2one )
Pig_ DNAJB2 ( ortholog_one2one )
Rat_ Dnajb2 ( ortholog_one2one )
Rabbit_ DNAJB2 ( ortholog_one2one )
OhnologsDNAJB6, DNAJB7, DNAJB8
ParalogsDNAJB9, DNAJB14, DNAJB6, DNAJB7, DNAJB12, DNAJB13, DNAJB4, DNAJB1, DNAJB8, DNAJB5, DNAJB11
TissueNA
Tissue SpecificityMore abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:1599432, PubMed:12754272). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:1599432}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2LGW  (NMR 
DBSNP rs730882140  rs34127289 
Subcellular location [CC][Isoform 2]: Cytoplasm {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:21625540}. Nucleus {ECO:0000269|PubMed:12754272}.;
[Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12754272};
Lipid-anchor {ECO:0000269|PubMed:12754272};
Cytoplasmic side {ECO:0000269|PubMed:12754272}.
Mouse PG classificationNA
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