| Gene Information | |
|---|---|
| Gene Name | FAM82C |
| Organism | Homo sapiens (Human) |
| Gene Length | 470 |
| Protein Names | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96TC7 |
| Gene Card | RMDN3 |
| Uniprot ID | Q96TC7 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed. {ECO:0000269|PubMed:15609043, ECO:0000269|PubMed:16820967}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7CC7 (X-ray 1.45A ) |
| DBSNP | rs11558807 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:17361080, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:29858488}; Single-pass membrane protein {ECO:0000269|PubMed:16820967}. Cytoplasm {ECO:0000269|PubMed:17361080}. Nucleus {ECO:0000269|PubMed:17361080}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. {ECO:0000269|PubMed:18070910}. |
| Mouse PG classification | NA |
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