| Gene Information | |
|---|---|
| Gene Name | CSVP |
| Organism | Homo sapiens (Human) |
| Gene Length | 824 |
| Protein Names | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P78536 |
| Gene Card | ADAM17 |
| Uniprot ID | P78536 |
| Pfam | PF16698; PF00200; PF01562 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. Expressed in natural killer cells (at protein level) (PubMed:24337742). {ECO:0000269|PubMed:24337742}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BKC (X-ray 2.00A ) 1ZXC (X-ray 2.28A ) 2A8H (X-ray 2.30A ) 2DDF (X-ray 1.70A ) 2FV5 (X-ray 2.10A ) 2FV9 (X-ray 2.02A ) 2I47 (X-ray 1.90A ) 2M2F (NMR - ) 2OI0 (X-ray 2.00A ) 3B92 (X-ray 2.00A ) 3CKI (X-ray 2.30A ) 3E8R (X-ray 1.90A ) 3EDZ (X-ray 1.90A ) 3EWJ (X-ray 1.80A ) 3G42 (X-ray 2.10A ) 3KMC (X-ray 1.80A ) 3KME (X-ray 1.85A ) 3L0T (X-ray 1.92A ) 3L0V (X-ray 1.75A ) 3LE9 (X-ray 1.85A ) 3LEA (X-ray 2.00A ) 3LGP (X-ray 1.90A ) 3O64 (X-ray 1.88A ) |
| DBSNP | rs34431503 rs2230818 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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