| Gene Information | |
|---|---|
| Gene Name | GPR18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 331 |
| Protein Names | N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18) |
| Target Name | n-arachidonyl glycine receptor |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000125245 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14330 |
| Gene Card | GPR18 |
| Uniprot ID | Q14330 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.729619931) |
| Ortholog in Animals | Alpaca_ GPR18 ( ortholog_one2one ) Dog_ GPR18 ( ortholog_one2one ) GuineaPig_ GPR18 ( ortholog_one2one ) Macaque_ GPR18 ( ortholog_one2one ) Mouse_ Gpr18 ( ortholog_one2one ) Pig_ GPR18 ( ortholog_one2one ) Rat_ Gpr18 ( ortholog_one2one ) Rabbit_ GPR18 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPR20, LPAR4, LPAR6, P2RY10, GPR35, GPR55, F2RL2, P2RY8, F2RL1, F2R, F2RL3, CYSLTR2, CYSLTR1, GPR17, GPR65, GPR4 |
| Tissue | lymph.node, appendix, tonsil, spleen, testis |
| Tissue Specificity | Expressed in midpiece of spermatozoon (at protein level) (PubMed:27572937). Most abundant in testis and spleen (PubMed:16844083). Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells (PubMed:16844083). {ECO:0000269|PubMed:16844083, ECO:0000269|PubMed:27572937}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24762058, ECO:0000269|PubMed:27018161}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:24762058}. |
| Mouse PG classification | NA |
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