| Gene Information | |
|---|---|
| Gene Name | DAB2IP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1189 |
| Protein Names | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000136848 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q5VWQ8 |
| Gene Card | DAB2IP |
| Uniprot ID | Q5VWQ8 |
| Pfam | PF00168; PF12004; PF00616 |
| In ASD | no |
| Allosteric Prediction | no (-0.536999691) |
| Ortholog in Animals | Alpaca_ DAB2IP ( ortholog_one2one ) Dog_ DAB2IP ( ortholog_one2one ) GuineaPig_ DAB2IP ( ortholog_one2one ) Macaque_ DAB2IP ( ortholog_one2one ) Mouse_ Dab2ip ( ortholog_one2one ) Pig_ DAB2IP ( ortholog_one2one ) Rat_ Dab2ip ( ortholog_one2one ) Rabbit_ DAB2IP ( ortholog_one2one ) |
| Ohnologs | RASAL3, RASAL2, SYNGAP1 |
| Paralogs | NF1, SYNGAP1, RASAL1, RASA3, RASA1, RASA2, RASA4, RASA4B, RASAL2, RASAL3 |
| Tissue | NA |
| Tissue Specificity | Expressed in endothelial and vascular smooth muscle cells (VSMCs). Expressed in prostate epithelial but poorly in prostate cancer cells. Poorly expressed in medulloblastoma cells compared to cerebellar precursor proliferating progenitor cells (at protein level). Low expression in prostate. Down-regulated in prostate cancer. {ECO:0000269|PubMed:11944990, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs7027492 |
| Subcellular location [CC] | Cytoplasm. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane. Cell projection, dendrite {ECO:0000250}. Note=Localized in soma and dendrites of Purkinje cells as well as in scattered cell bodies in the molecular layer of the cerebellum (By similarity). Colocalizes with TIRAP at the plasma membrane. Colocalizes with ARF6 at the plasma membrane and endocytic vesicles. Translocates from the plasma membrane to the cytoplasm in response to TNF-alpha. Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for plasma membrane localization. {ECO:0000250}. |
| Mouse PG classification | NA |
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