| Gene Information | |
|---|---|
| Gene Name | OSBPL1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 950 |
| Protein Names | Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000141447 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BXW6 |
| Gene Card | OSBPL1A |
| Uniprot ID | Q9BXW6 |
| Pfam | PF12796; PF13857; PF01237 |
| In ASD | no |
| Allosteric Prediction | no (-0.29855262) |
| Ortholog in Animals | Alpaca_ OSBPL1A ( ortholog_one2one ) Dog_ OSBPL1A ( ortholog_one2one ) GuineaPig_ OSBPL1A ( ortholog_one2one ) Macaque_ OSBPL1A ( ortholog_one2one ) Mouse_ Osbpl1a ( ortholog_one2one ) Pig_ OSBPL1A ( ortholog_one2one ) Rat_ Osbpl1a ( ortholog_one2one ) Rabbit_ OSBPL1A ( ortholog_one2one ) |
| Ohnologs | OSBPL2 |
| Paralogs | OSBPL10, OSBPL2, OSBP2, OSBP, OSBPL8, OSBPL3, OSBPL5, OSBPL9, OSBPL11, OSBPL6, OSBPL7 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5ZM5 (X-ray 2.60A ) 5ZM6 (X-ray 2.70A ) 5ZM7 (X-ray 3.40A ) 6IYB (X-ray 2.09A ) 6TQS (X-ray 2.25A ) |
| DBSNP | rs35693789 |
| Subcellular location [CC] | Late endosome {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:29858488}. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes. |
| Mouse PG classification | NA |
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