| Gene Information | |
|---|---|
| Gene Name | NFAT5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1531 |
| Protein Names | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000102908 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O94916 |
| Gene Card | NFAT5 |
| Uniprot ID | O94916 |
| Pfam | PF16179; PF00554 |
| In ASD | no |
| Allosteric Prediction | no (-0.179672759) |
| Ortholog in Animals | Alpaca_ NFAT5 ( ortholog_one2one ) Dog_ NFAT5 ( ortholog_one2one ) GuineaPig_ NFAT5 ( ortholog_one2one ) Macaque_ NFAT5 ( ortholog_one2one ) Mouse_ Nfat5 ( ortholog_one2one ) Pig_ NFAT5 ( ortholog_one2one ) Rat_ Nfat5 ( ortholog_one2one ) Rabbit_ NFAT5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NFATC3, NFATC4, NFATC1, NFATC2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1IMH (X-ray 2.86A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10377394}. Cytoplasm {ECO:0000250|UniProtKB:Q9WV30}. Chromosome {ECO:0000269|PubMed:34049076}. Note=Nuclear distribution increases under hypertonic conditions (By similarity). Recruited to sites of R-loop-associated DNA damage following poly-ADP-ribosylation by PARP1 (PubMed:34049076). {ECO:0000250|UniProtKB:Q9WV30, ECO:0000269|PubMed:34049076}. |
| Mouse PG classification | NA |
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