Gene Information
Gene NameDHRS7
OrganismHomo sapiens (Human)
Gene Length339
Protein NamesDehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000100612 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y394
Gene CardDHRS7
Uniprot IDQ9Y394
PfamPF00106
In ASDno
Allosteric Predictionyes (0.037851486)
Ortholog in AnimalsAlpaca_ DHRS7 ( ortholog_one2one )
Dog_ DHRS7 ( ortholog_one2one )
Macaque_ DHRS7 ( ortholog_one2one )
Mouse_ Gm4756 ( ortholog_one2many )
Mouse_ Dhrs7 ( ortholog_one2many )
Pig_ DHRS7 ( ortholog_one2one )
Rat_ Dhrs7 ( ortholog_one2many )
Rat_ Dhrs7l1 ( ortholog_one2many )
Rabbit_ DHRS7 ( ortholog_one2one )
OhnologsNA
ParalogsDHRS7C, HSD11B1, RDH8, CBR3, HSDL2, DHRS7B, DHRS2, HSD11B1L, DHRS4L2, DHRS4, DHRS11, CBR1, DHRS1
TissueNA
Tissue SpecificityFound predominantly in the adrenal glands, liver, thyroid, prostate, small intestine, colon, stomach, kidney and brain (PubMed:26466768). Lower levels observed in skeletal muscle, the lung and the spleen (PubMed:26466768). {ECO:0000269|PubMed:26466768}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs34583017 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:28457967}. Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum (PubMed:24246760). However, it was later shown to be facing the cytosol (PubMed:28457967). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:28457967}.
Mouse PG classificationNA
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