| Gene Information | |
|---|---|
| Gene Name | CHRDL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 429 |
| Protein Names | Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000054938 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6WN34 |
| Gene Card | CHRDL2 |
| Uniprot ID | Q6WN34 |
| Pfam | PF19548; PF00093 |
| In ASD | no |
| Allosteric Prediction | no (-1.454469279) |
| Ortholog in Animals | Alpaca_ CHRDL2 ( ortholog_one2one ) Dog_ CHRDL2 ( ortholog_one2one ) GuineaPig_ CHRDL2 ( ortholog_one2one ) Macaque_ CHRDL2 ( ortholog_one2one ) Mouse_ Chrdl2 ( ortholog_one2one ) Pig_ CHRDL2 ( ortholog_one2one ) Rat_ Chrdl2 ( ortholog_one2one ) Rabbit_ CHRDL2 ( ortholog_one2one ) |
| Ohnologs | CHRDL1 |
| Paralogs | CHRDL1, MUC5B, KCP, CHRD, VWF, VWCE, OTOGL, MUC6, MUC5AC, OTOG, ZAN, BMPER, TECTA, FCGBP, CRIM1, MUC2, MUC19, VWC2L, VWC2 |
| Tissue | appendix, endometrium, gall.bladder, smooth.muscle, urinary.bladder, sigmoid.colon, uterus |
| Tissue Specificity | Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma. {ECO:0000269|PubMed:12853144, ECO:0000269|PubMed:14660436, ECO:0000269|PubMed:15094188}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35903991 |
| Subcellular location [CC] | [Isoform 1]: Secreted {ECO:0000305}.; [Isoform 2]: Secreted {ECO:0000305}.; [Isoform 3]: Cytoplasm {ECO:0000305}.; [Isoform 4]: Cytoplasm {ECO:0000305}.; [Isoform 5]: Cytoplasm {ECO:0000305}. |
| Mouse PG classification | NA |
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