Gene Information
Gene NameIGF2R
OrganismHomo sapiens (Human)
Gene Length2491
Protein NamesCation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
Target Nameci man-6-p receptor
Target TypeClinical trial target
Gene Age950 ( ENSG00000197081 )
Evolutionary StageOpisthokonta
AlphaFoldDBP11717
Gene CardIGF2R
Uniprot IDP11717
PfamPF00878; PF00040
In ASDno
Allosteric Predictionyes (0.660813749)
Ortholog in AnimalsAlpaca_ IGF2R ( ortholog_one2one )
Dog_ IGF2R ( ortholog_one2one )
GuineaPig_ IGF2R ( ortholog_one2one )
Macaque_ IGF2R ( ortholog_one2one )
Mouse_ Igf2r ( ortholog_one2one )
Pig_ IGF2R ( ortholog_one2one )
Rat_ Igf2r ( ortholog_one2one )
Rabbit_ IGF2R ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1E6F  (X-ray  1.75A  )  1GP0  (X-ray  1.40A  )  1GP3  (X-ray  1.95A  )  1GQB  (X-ray  1.80A  )  1JPL  (X-ray  2.40A  )  1JWG  (X-ray  2.00A  )  1LF8  (X-ray  2.30A  )  2CNJ  (NMR  -  )  2L29  (NMR  -  )  2L2A  (NMR  -  )  2M68  (NMR  -  )  2M6T  (NMR  -  )  2V5N  (X-ray  3.20A  )  2V5O  (X-ray  2.91A  )  2V5P  (X-ray  4.10A  )  5IEI  (X-ray  2.80A  )  6N5X  (X-ray  2.05A  )  6N5Y  (X-ray  2.26A  )  6P8I  (X-ray  2.54A  )  6V02  (X-ray  2.46A  )  6Z30  (X-ray  1.50A  )  6Z31  (X-ray  2.56A  )  6Z32  (X-ray  3.47A  ) 
DBSNP rs8191704  rs8191746  rs8191753  rs8191754  rs8191758  rs8191776  rs6413489  rs8191797  rs6413491  rs8191808  rs8191819  rs8191842  rs8191843  rs8191844  rs2230043  rs8191859  rs8191860  rs2230048  rs629849  rs11552587  rs8191904  rs8191905  rs8191908  rs1805075  rs8191955 
Subcellular location [CC]Golgi apparatus membrane {ECO:0000269|PubMed:18817523};
Single-pass type I membrane protein {ECO:0000269|PubMed:2957598}. Endosome membrane {ECO:0000269|PubMed:18817523};
Single-pass type I membrane protein {ECO:0000269|PubMed:2957598}. Note=Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18817523}.
Mouse PG classificationNA
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