| Gene Information | |
|---|---|
| Gene Name | NETO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 533 |
| Protein Names | Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000166342 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TDF5 |
| Gene Card | NETO1 |
| Uniprot ID | Q8TDF5 |
| Pfam | PF00431; PF00057 |
| In ASD | no |
| Allosteric Prediction | no (-0.180276571) |
| Ortholog in Animals | Alpaca_ NETO1 ( ortholog_one2one ) Dog_ NETO1 ( ortholog_one2one ) GuineaPig_ NETO1 ( ortholog_one2one ) Macaque_ NETO1 ( ortholog_one2one ) Mouse_ Neto1 ( ortholog_one2one ) Pig_ NETO1 ( ortholog_one2one ) Rat_ Neto1 ( ortholog_one2one ) Rabbit_ NETO1 ( ortholog_one2one ) |
| Ohnologs | NETO2 |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain. {ECO:0000269|PubMed:11943477}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs922999 rs17086286 |
| Subcellular location [CC] | [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250}. Note=Component of the postsynaptic density (PSD) of excitatory synapses. {ECO:0000250}.; [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 1]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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