| Gene Information | |
|---|---|
| Gene Name | PDK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 406 |
| Protein Names | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) |
| Target Name | [pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000067992 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15120 |
| Gene Card | PDK3 |
| Uniprot ID | Q15120 |
| Pfam | PF10436; PF02518 |
| In ASD | no |
| Allosteric Prediction | yes (0.365604773) |
| Ortholog in Animals | Alpaca_ PDK3 ( ortholog_one2one ) Dog_ PDK3 ( ortholog_one2one ) GuineaPig_ PDK3 ( ortholog_one2one ) Macaque_ PDK3 ( ortholog_one2one ) Mouse_ Pdk3 ( ortholog_one2one ) Pig_ PDK3 ( ortholog_one2one ) Rat_ Pdk3 ( ortholog_one2one ) Rabbit_ PDK3 ( ortholog_one2one ) |
| Ohnologs | PDK4 |
| Paralogs | PDK4, PDK2, PDK1, BCKDK |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. {ECO:0000269|PubMed:23297365}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Y8N (X-ray 2.60A ) 1Y8O (X-ray 2.48A ) 1Y8P (X-ray 2.63A ) 2PNR (X-ray 2.50A ) 2Q8I (X-ray 2.60A ) |
| DBSNP | rs146331370 rs397515323 |
| Subcellular location [CC] | Mitochondrion matrix. |
| Mouse PG classification | NA |
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