Gene Information
Gene NameRTN4RL2
OrganismHomo sapiens (Human)
Gene Length420
Protein NamesReticulon-4 receptor-like 2 (Nogo receptor-like 3) (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000186907 )
Evolutionary StageEumetazoa
AlphaFoldDBQ86UN3
Gene CardRTN4RL2
Uniprot IDQ86UN3
PfamPF13855
In ASDno
Allosteric Predictionno (-0.951135824)
Ortholog in AnimalsAlpaca_ RTN4RL2 ( ortholog_one2one )
Dog_ RTN4RL2 ( ortholog_one2one )
GuineaPig_ RTN4RL2 ( ortholog_one2one )
Macaque_ RTN4RL2 ( ortholog_one2one )
Mouse_ Rtn4rl2 ( ortholog_one2one )
Pig_ RTN4RL2 ( ortholog_one2one )
Rat_ Rtn4rl2 ( ortholog_one2one )
OhnologsNA
ParalogsLRTM1, LRRTM3, BGN, LRRTM1, LRRC19, LRRC4B, NYX, PODN, LRRC15, FLRT2, FLRT1, LRRTM4, LRRC66, RTN4RL1, LRRC4, ASPN, PODNL1, FLRT3, DCN, GP1BA, RTN4R, LRRC4C
Tissuebrain, liver, thyroid
Tissue SpecificityHighly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid. {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:14664809}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:12839991};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12694398}. Membrane raft {ECO:0000269|PubMed:12694398}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7M6Z0}. Perikaryon {ECO:0000250|UniProtKB:Q80WD1}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WD1}. Note=Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. {ECO:0000250|UniProtKB:Q7M6Z0}.
Mouse PG classificationNA
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