| Gene Information | |
|---|---|
| Gene Name | FAS |
| Organism | Homo sapiens (Human) |
| Gene Length | 2511 |
| Protein Names | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] |
| Target Name | apoptosis mediating surface antigen fas |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000026103 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P49327 |
| Gene Card | FASN |
| Uniprot ID | P49327 |
| Pfam | PF00698; PF00107; PF16197; PF00109; PF02801; PF08659; PF08242; PF00550; PF14765; PF00975 |
| In ASD | yes |
| Allosteric Prediction | yes (1.190496079) |
| Ortholog in Animals | Alpaca_ FAS ( ortholog_one2one ) Dog_ FAS ( ortholog_one2one ) GuineaPig_ FAS ( ortholog_one2one ) Mouse_ Fas ( ortholog_one2one ) Pig_ FAS ( ortholog_one2one ) Rat_ Fas ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Prominent expression in brain, lung, liver and mammary gland. {ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:7595075}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1XKT (X-ray 2.60A ) 2CG5 (X-ray 2.70A ) 2JFD (X-ray 2.81A ) 2JFK (X-ray 2.40A ) 2PX6 (X-ray 2.30A ) 3HHD (X-ray 2.15A ) 3TJM (X-ray 1.48A ) 4PIV (X-ray 2.30A ) 4W82 (X-ray 1.70A ) 4W9N (X-ray 1.84A ) 4Z49 (X-ray 1.70A ) 5C37 (X-ray 2.30A ) 6NNA (X-ray 2.26A ) 7MHD (X-ray 2.03A ) 7MHE (X-ray 2.80A ) |
| DBSNP | rs113931914 rs2228305 rs561903908 rs2228307 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Mouse PG classification | HPG |
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