| Gene Information | |
|---|---|
| Gene Name | BEST3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 668 |
| Protein Names | Bestrophin-3 (Vitelliform macular dystrophy 2-like protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000127325 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N1M1 |
| Gene Card | BEST3 |
| Uniprot ID | Q8N1M1 |
| Pfam | PF01062 |
| In ASD | no |
| Allosteric Prediction | no (-0.965525212) |
| Ortholog in Animals | Alpaca_ BEST3 ( ortholog_one2one ) Dog_ BEST3 ( ortholog_one2one ) GuineaPig_ BEST3 ( ortholog_one2one ) Macaque_ BEST3 ( ortholog_one2one ) Mouse_ Best3 ( ortholog_one2one ) Pig_ BEST3 ( ortholog_one2one ) Rat_ Best3 ( ortholog_one2one ) Rabbit_ BEST3 ( ortholog_one2one ) |
| Ohnologs | BEST1 |
| Paralogs | BEST1, BEST4, BEST2 |
| Tissue | artery, tongue |
| Tissue Specificity | Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina. {ECO:0000269|PubMed:12032738}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1025016 rs17106884 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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