| Gene Information | |
|---|---|
| Gene Name | ERAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 960 |
| Protein Names | Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000164308 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q6P179 |
| Gene Card | ERAP2 |
| Uniprot ID | Q6P179 |
| Pfam | PF11838; PF01433; PF17900 |
| In ASD | no |
| Allosteric Prediction | yes (0.138552464) |
| Ortholog in Animals | Alpaca_ ERAP2 ( ortholog_one2one ) Macaque_ ERAP2 ( ortholog_one2one ) Pig_ ERAP2 ( ortholog_one2one ) |
| Ohnologs | ANPEP |
| Paralogs | RNPEPL1, NPEPPS, ERAP1, ENPEP, AOPEP, LTA4H, TRHDE, LNPEP, LVRN, ANPEP, RNPEP |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in spleen and leukocytes. {ECO:0000269|PubMed:12799365}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3SE6 (X-ray 3.08A ) 4E36 (X-ray 3.22A ) 4JBS (X-ray 2.79A ) 5AB0 (X-ray 2.50A ) 5AB2 (X-ray 2.73A ) 5CU5 (X-ray 3.02A ) 5J6S (X-ray 2.80A ) 5K1V (X-ray 2.90A ) 6EA4 (X-ray 2.45A ) 7NSK (X-ray 3.10A ) 7NUP (X-ray 3.10A ) 7P7P (X-ray 3.00A ) 7PFS (X-ray 2.70A ) 7SH0 (X-ray 3.20A ) |
| DBSNP | rs3733905 rs2549782 rs34261036 rs17408150 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269|PubMed:12799365}. |
| Mouse PG classification | NA |
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