| Gene Information | |
|---|---|
| Gene Name | TOPBP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1522 |
| Protein Names | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000163781 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92547 |
| Gene Card | TOPBP1 |
| Uniprot ID | Q92547 |
| Pfam | PF00533 |
| In ASD | no |
| Allosteric Prediction | no (-0.203087095) |
| Ortholog in Animals | Alpaca_ TOPBP1 ( ortholog_one2one ) Dog_ TOPBP1 ( ortholog_one2one ) GuineaPig_ TOPBP1 ( ortholog_one2one ) Macaque_ TOPBP1 ( ortholog_one2one ) Mouse_ Topbp1 ( ortholog_one2one ) Pig_ TOPBP1 ( ortholog_one2one ) Rat_ Topbp1 ( ortholog_one2one ) Rabbit_ TOPBP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLF1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, brain, placenta, lung and kidney. {ECO:0000269|PubMed:9461304}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WF6 (NMR - ) 2XNH (X-ray 2.80A ) 2XNK (X-ray 2.60A ) 3AL2 (X-ray 2.00A ) 3AL3 (X-ray 2.15A ) 3JVE (X-ray 1.34A ) 3OLC (X-ray 2.40A ) 3PD7 (X-ray 1.26A ) 3UEN (X-ray 1.90A ) 3UEO (X-ray 2.60A ) 6RML (X-ray 2.81A ) 6RMM (X-ray 3.53A ) 7CMZ (X-ray 1.70A ) |
| DBSNP | rs17301766 rs10935070 rs10935070 |
| Subcellular location [CC] | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |