| Gene Information | |
|---|---|
| Gene Name | PLD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 490 |
| Protein Names | 5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Phospholipase D3) (PLD 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000105223 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IV08 |
| Gene Card | PLD3 |
| Uniprot ID | Q8IV08 |
| Pfam | PF13918 |
| In ASD | no |
| Allosteric Prediction | no (-0.325078111) |
| Ortholog in Animals | Alpaca_ PLD3 ( ortholog_one2one ) Dog_ PLD3 ( ortholog_one2one ) GuineaPig_ PLD3 ( ortholog_one2one ) Macaque_ PLD3 ( ortholog_one2one ) Mouse_ Pld3 ( ortholog_one2one ) Pig_ PLD3 ( ortholog_one2one ) Rat_ Pld3 ( ortholog_one2one ) Rabbit_ PLD3 ( ortholog_one2one ) |
| Ohnologs | PLD4 |
| Paralogs | PLD5, PLD4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum. {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:24336208}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs142070038 rs138674695 rs374184677 rs866850284 rs780604999 rs1326374111 rs765630414 rs145999145 rs757965784 rs746715924 rs144312764 rs200274020 rs368737000 rs146083475 rs537053537 rs370488565 rs745463234 rs986006936 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}; Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Lysosome lumen {ECO:0000269|PubMed:29386126, ECO:0000269|PubMed:30312375}. Early endosome membrane {ECO:0000269|PubMed:29386126}; Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Late endosome membrane {ECO:0000269|PubMed:29386126}; Single-pass type II membrane protein {ECO:0000269|PubMed:15794758, ECO:0000269|PubMed:22428023}. Golgi apparatus membrane {ECO:0000269|PubMed:29368044}; Single-pass type II membrane protein {ECO:0000269|PubMed:29368044}. Endosome membrane {ECO:0000269|PubMed:29368044}; Single-pass type II membrane protein {ECO:0000269|PubMed:29368044}. Note=Localizes to ER-associated vesicles in differentiating myotubes (PubMed:22428023). The soluble form in lysosome arises by proteolytic processing of the membrane-bound form (PubMed:29386126). Colocalizes with APP in endosomes (PubMed:29368044). {ECO:0000269|PubMed:22428023, ECO:0000269|PubMed:29368044, ECO:0000269|PubMed:29386126}. |
| Mouse PG classification | NA |
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