| Gene Information | |
|---|---|
| Gene Name | CLK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 638 |
| Protein Names | Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3) |
| Target Name | dual specificity protein kinase clk3 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000179335 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49761 |
| Gene Card | CLK3 |
| Uniprot ID | P49761 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.561561148) |
| Ortholog in Animals | Alpaca_ CLK3 ( ortholog_one2one ) Dog_ CLK3 ( ortholog_one2one ) GuineaPig_ CLK3 ( ortholog_one2one ) Macaque_ CLK3 ( ortholog_one2one ) Mouse_ Clk3 ( ortholog_one2one ) Pig_ CLK3 ( ortholog_one2one ) Rat_ Clk3 ( ortholog_one2one ) Rabbit_ CLK3 ( ortholog_one2one ) |
| Ohnologs | CLK2 |
| Paralogs | CLK1, HIPK3, DYRK4, DYRK1B, HIPK1, HIPK4, DYRK3, HIPK2, CLK4, DYRK2, DYRK1A, CLK2 |
| Tissue | NA |
| Tissue Specificity | Endothelial cells. {ECO:0000269|PubMed:19168442}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EU9 (X-ray 1.53A ) 2EXE (X-ray 2.35A ) 2WU6 (X-ray 1.92A ) 2WU7 (X-ray 2.25A ) 3RAW (X-ray 2.09A ) 6FT7 (X-ray 2.02A ) 6FYP (X-ray 2.29A ) 6FYR (X-ray 1.42A ) 6KHF (X-ray 2.60A ) 6RCT (X-ray 2.32A ) 6YTW (X-ray 2.00A ) 6YTY (X-ray 1.76A ) 6YU1 (X-ray 1.90A ) 6Z2V (X-ray 2.60A ) 6Z51 (X-ray 1.92A ) 6Z52 (X-ray 2.12A ) 6Z53 (X-ray 1.65A ) 6Z54 (X-ray 1.73A ) 6Z55 (X-ray 1.70A ) |
| DBSNP | rs975796055 rs910378995 rs920443187 |
| Subcellular location [CC] | [Isoform 1]: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.; [Isoform 2]: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. |
| Mouse PG classification | NA |
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