| Gene Information | |
|---|---|
| Gene Name | KLRB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 225 |
| Protein Names | Killer cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000111796 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q12918 |
| Gene Card | KLRB1 |
| Uniprot ID | Q12918 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.890433519) |
| Ortholog in Animals | Alpaca_ KLRB1 ( ortholog_one2one ) Dog_ KLRB1 ( ortholog_one2one ) Macaque_ KLRB1 ( ortholog_one2one ) Mouse_ Klrb1a ( ortholog_one2many ) Mouse_ Klrb1b ( ortholog_one2many ) Mouse_ Klrb1c ( ortholog_one2many ) Mouse_ Klrb1 ( ortholog_one2many ) Mouse_ Klrb1f ( ortholog_one2many ) Pig_ KLRB1 ( ortholog_one2one ) Rat_ Klrb1c ( ortholog_one2many ) Rat_ Klrb1 ( ortholog_one2many ) Rat_ Klrb1a ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CD69, CLEC12A, KLRC3, KLRC2, CLEC12B, OLR1, KLRG2, CLEC2A, KLRF1, CLEC1A, KLRF2, KLRD1, CLEC2B, KLRC1, CLEC2L, KLRG1, CLEC9A, CLEC1B, KLRC4, KLRK1, CLEC5A, CLEC2D, CLEC7A |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. {ECO:0000269|PubMed:12100027, ECO:0000269|PubMed:8077657}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5MGR (X-ray 1.80A ) 5MGS (X-ray 1.90A ) 5MGT (X-ray 1.90A ) |
| DBSNP | rs1135816 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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