| Gene Information | |
|---|---|
| Gene Name | PUS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000177192 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y606 |
| Gene Card | PUS1 |
| Uniprot ID | Q9Y606 |
| Pfam | PF01416 |
| In ASD | no |
| Allosteric Prediction | no (-1.753093667) |
| Ortholog in Animals | Alpaca_ PUS1 ( ortholog_one2one ) Dog_ PUS1 ( ortholog_one2one ) GuineaPig_ PUS1 ( ortholog_one2one ) Macaque_ PUS1 ( ortholog_one2one ) Mouse_ Pus1 ( ortholog_one2one ) Pig_ PUS1 ( ortholog_one2one ) Rat_ Pus1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PUS3, PUSL1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:15108122). High levels of expression found in brain and skeletal muscle (PubMed:15108122). {ECO:0000269|PubMed:15108122}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4IQM (X-ray 1.80A ) 4ITS (X-ray 1.85A ) 4J37 (X-ray 1.75A ) 4NZ6 (X-ray 2.00A ) 4NZ7 (X-ray 2.70A ) |
| DBSNP | rs76655496 rs104894371 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:17056637, ECO:0000305|PubMed:15772074}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:17056637, ECO:0000305|PubMed:15772074}. Cytoplasm {ECO:0000305|PubMed:15772074}. |
| Mouse PG classification | LPG |
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