| Gene Information | |
|---|---|
| Gene Name | FAF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 650 |
| Protein Names | FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) |
| Target Name | fas-associated factor 1 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000185104 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UNN5 |
| Gene Card | FAF1 |
| Uniprot ID | Q9UNN5 |
| Pfam | PF00789 |
| In ASD | no |
| Allosteric Prediction | yes (0.310858286) |
| Ortholog in Animals | Alpaca_ FAF1 ( ortholog_one2one ) Dog_ FAF1 ( ortholog_one2one ) GuineaPig_ FAF1 ( ortholog_one2one ) Macaque_ FAF1 ( ortholog_one2one ) Mouse_ Faf1 ( ortholog_one2one ) Pig_ FAF1 ( ortholog_one2one ) Rat_ Faf1 ( ortholog_one2one ) Rabbit_ FAF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBXN7, FAF2, UBXN8, UBXN10 |
| Tissue | NA |
| Tissue Specificity | Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes. {ECO:0000269|PubMed:10462485}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1H8C (NMR - ) 2DZM (NMR - ) 2EC4 (NMR - ) 3E21 (X-ray 1.73A ) 3QC8 (X-ray 2.20A ) 3QCA (X-ray 2.90A ) 3QQ8 (X-ray 2.00A ) 3QWZ (X-ray 2.00A ) 3QX1 (X-ray 1.60A ) 3R3M (X-ray 3.00A ) 7FGM (X-ray 2.20A ) 7FGN (X-ray 1.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26842564}. |
| Mouse PG classification | NA |
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