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Gene Information
Gene Name
CSNK2A1
Organism
Homo sapiens (Human)
Gene Length
391
Protein Names
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Target Name
casein kinase ii alpha
Target Type
Clinical trial target
Gene Age
382 ( ENSG00000101266 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P68400
Gene Card
CSNK2A1
Uniprot ID
P68400
Pfam
PF00069
In ASD
yes
Allosteric Prediction
yes (1.174239677)
Ortholog in Animals
Dog_ CSNK2A1 ( ortholog_one2many )
Mouse_ Csnk2a1 ( ortholog_one2many )
Rat_ Csnk2a1 ( ortholog_one2many )
Ohnologs
NA
Paralogs
CSNK2A3, CSNK2A2
Tissue
NA
Tissue Specificity
Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). {ECO:0000269|PubMed:24962073}.
Pharmacological Animal Models
NULL(Chimpanzee);0.269153(Mouse);NULL(Rat);0.014035(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1JWH
(X-ray
3.10A
)
1NA7
(X-ray
2.40A
)
1PJK
(X-ray
2.50A
)
2PVR
(X-ray
1.60A
)
2ZJW
(X-ray
2.40A
)
3AMY
(X-ray
2.30A
)
3AT2
(X-ray
1.60A
)
3AT3
(X-ray
2.60A
)
3AT4
(X-ray
2.20A
)
3AXW
(X-ray
2.50A
)
3BQC
(X-ray
1.50A
)
3C13
(X-ray
1.95A
)
3FWQ
(X-ray
2.30A
)
3H30
(X-ray
1.56A
)
3JUH
(X-ray
1.66A
)
3MB6
(X-ray
1.75A
)
3MB7
(X-ray
1.65A
)
3NGA
(X-ray
2.71A
)
3NSZ
(X-ray
1.30A
)
3OWJ
(X-ray
1.85A
)
3OWK
(X-ray
1.80A
)
3OWL
(X-ray
2.10A
)
3PE1
(X-ray
1.60A
)
3PE2
(X-ray
1.90A
)
3PE4
(X-ray
1.95A
)
3Q04
(X-ray
1.80A
)
3Q9W
(X-ray
1.70A
)
3Q9X
(X-ray
2.20A
)
3Q9Y
(X-ray
1.80A
)
3Q9Z
(X-ray
2.20A
)
3QA0
(X-ray
2.50A
)
3R0T
(X-ray
1.75A
)
3RPS
(X-ray
2.30A
)
3TAX
(X-ray
1.88A
)
3U4U
(X-ray
2.20A
)
3U87
(X-ray
2.90A
)
3U9C
(X-ray
3.20A
)
3W8L
(X-ray
2.40A
)
3WAR
(X-ray
1.04A
)
3WIK
(X-ray
2.00A
)
3WIL
(X-ray
2.90A
)
3WOW
(X-ray
2.50A
)
4DGL
(X-ray
3.00A
)
4FBX
(X-ray
2.33A
)
4GRB
(X-ray
2.15A
)
4GUB
(X-ray
2.20A
)
4GYW
(X-ray
1.70A
)
4GYY
(X-ray
1.85A
)
4GZ3
(X-ray
1.90A
)
4IB5
(X-ray
2.20A
)
4KWP
(X-ray
1.25A
)
4MD7
(X-ray
3.10A
)
4MD8
(X-ray
3.30A
)
4MD9
(X-ray
3.50A
)
4NH1
(X-ray
3.30A
)
4RLL
(X-ray
1.85A
)
4UB7
(X-ray
2.10A
)
4UBA
(X-ray
3.00A
)
5B0X
(X-ray
2.30A
)
5CLP
(X-ray
1.68A
)
5CQU
(X-ray
2.35A
)
5CQW
(X-ray
2.65A
)
5CS6
(X-ray
1.88A
)
5CSH
(X-ray
1.59A
)
5CSP
(X-ray
1.50A
)
5CSV
(X-ray
1.38A
)
5CT0
(X-ray
2.01A
)
5CTP
(X-ray
2.03A
)
5CU0
(X-ray
2.18A
)
5CU2
(X-ray
1.71A
)
5CU3
(X-ray
1.79A
)
5CU4
(X-ray
1.56A
)
5CU6
(X-ray
1.36A
)
5CVF
(X-ray
1.63A
)
5CVG
(X-ray
1.25A
)
5CVH
(X-ray
1.85A
)
5CX9
(X-ray
1.73A
)
5H8B
(X-ray
2.55A
)
5H8E
(X-ray
2.15A
)
5H8G
(X-ray
2.00A
)
5HGV
(X-ray
2.05A
)
5KU8
(X-ray
2.22A
)
5KWH
(X-ray
2.12A
)
5M44
(X-ray
2.71A
)
5M4C
(X-ray
1.94A
)
5M4F
(X-ray
1.52A
)
5M4I
(X-ray
2.22A
)
5MMF
(X-ray
1.99A
)
5MMR
(X-ray
2.00A
)
5MO5
(X-ray
2.04A
)
5MO6
(X-ray
1.82A
)
5MO7
(X-ray
2.15A
)
5MO8
(X-ray
1.82A
)
5MOD
(X-ray
2.08A
)
5MOE
(X-ray
1.89A
)
5MOH
(X-ray
1.38A
)
5MOT
(X-ray
2.09A
)
5MOV
(X-ray
2.20A
)
5MOW
(X-ray
1.86A
)
5MP8
(X-ray
1.92A
)
5MPJ
(X-ray
2.14A
)
5N1V
(X-ray
2.52A
)
5N9K
(X-ray
1.64A
)
5N9L
(X-ray
1.79A
)
5N9N
(X-ray
1.84A
)
5NQC
(X-ray
2.00A
)
5OMY
(X-ray
1.95A
)
5ONI
(X-ray
2.00A
)
5OQU
(X-ray
2.32A
)
5ORH
(X-ray
1.75A
)
5ORJ
(X-ray
1.99A
)
5ORK
(X-ray
2.14A
)
5OS7
(X-ray
1.66A
)
5OS8
(X-ray
1.55A
)
5OSL
(X-ray
1.95A
)
5OSP
(X-ray
1.91A
)
5OSR
(X-ray
1.57A
)
5OSU
(X-ray
1.63A
)
5OSZ
(X-ray
2.00A
)
5OT5
(X-ray
1.63A
)
5OT6
(X-ray
1.94A
)
5OTD
(X-ray
1.57A
)
5OTH
(X-ray
1.69A
)
5OTI
(X-ray
1.59A
)
5OTL
(X-ray
1.57A
)
5OTO
(X-ray
1.51A
)
5OTP
(X-ray
1.57A
)
5OTQ
(X-ray
1.38A
)
5OTR
(X-ray
1.52A
)
5OTS
(X-ray
1.90A
)
5OTY
(X-ray
1.48A
)
5OTZ
(X-ray
1.46A
)
5OUE
(X-ray
2.01A
)
5OUL
(X-ray
1.34A
)
5OUM
(X-ray
2.05A
)
5OUU
(X-ray
1.81A
)
5OWH
(X-ray
2.30A
)
5OWL
(X-ray
2.23A
)
5OYF
(X-ray
1.54A
)
5T1H
(X-ray
2.11A
)
5VIE
(X-ray
2.60A
)
5VIF
(X-ray
2.25A
)
5ZN0
(Other
1.10A
)
5ZN1
(X-ray
1.05A
)
5ZN2
(X-ray
1.20A
)
5ZN3
(X-ray
1.50A
)
5ZN4
(X-ray
1.65A
)
5ZN5
(X-ray
1.70A
)
6A1C
(X-ray
1.68A
)
6E37
(X-ray
2.53A
)
6EHK
(X-ray
1.40A
)
6EHU
(X-ray
1.95A
)
6EII
(X-ray
1.94A
)
6FVF
(X-ray
1.47A
)
6FVG
(X-ray
1.60A
)
6GIH
(X-ray
1.96A
)
6GMD
(X-ray
1.66A
)
6HBN
(X-ray
1.59A
)
6HME
(X-ray
1.85A
)
6HNW
(X-ray
2.00A
)
6HNY
(X-ray
1.65A
)
6HOP
(X-ray
1.55A
)
6HOQ
(X-ray
1.55A
)
6HOR
(X-ray
1.80A
)
6HOT
(X-ray
1.50A
)
6HOU
(X-ray
1.80A
)
6JWA
(X-ray
1.78A
)
6L1Z
(X-ray
1.91A
)
6L21
(X-ray
2.05A
)
6L22
(X-ray
2.12A
)
6L23
(X-ray
1.97A
)
6L24
(X-ray
2.40A
)
6Q38
(X-ray
1.74A
)
6Q4Q
(X-ray
1.45A
)
6QY7
(X-ray
2.10A
)
6RB1
(X-ray
1.50A
)
6RCB
(X-ray
2.05A
)
6RCM
(X-ray
1.70A
)
6RFE
(X-ray
1.54A
)
6RFF
(X-ray
1.80A
)
6SPW
(X-ray
1.60A
)
6SPX
(X-ray
1.99A
)
6TEI
(X-ray
1.76A
)
6TLL
(X-ray
1.88A
)
6TLO
(X-ray
1.69A
)
6TLP
(X-ray
1.93A
)
6TLR
(X-ray
1.64A
)
6TLS
(X-ray
1.46A
)
6TLU
(X-ray
1.81A
)
6TLV
(X-ray
1.67A
)
6TLW
(X-ray
1.73A
)
6YPG
(X-ray
1.51A
)
6YPH
(X-ray
1.67A
)
6YPJ
(X-ray
1.64A
)
6YPK
(X-ray
1.79A
)
6YPN
(X-ray
1.58A
)
6YUL
(X-ray
2.40A
)
6YUM
(X-ray
2.75A
)
6YZH
(X-ray
1.19A
)
6Z19
(X-ray
1.47A
)
6Z83
(X-ray
2.17A
)
6Z84
(X-ray
2.50A
)
7A49
(X-ray
2.03A
)
7A4B
(X-ray
2.06A
)
7A4C
(X-ray
2.50A
)
7A4Q
(X-ray
1.42A
)
7AT5
(X-ray
1.77A
)
7AY9
(X-ray
2.25A
)
7AYA
(X-ray
2.45A
)
7B8H
(X-ray
1.34A
)
7B8I
(X-ray
2.55A
)
7BU4
(X-ray
1.70A
)
7L1X
(X-ray
1.80A
)
7PSU
(X-ray
1.77A
)
DBSNP
rs869312845
rs869312849
rs869312848
rs869312840
Subcellular location [CC]
Nucleus {ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073}.
Mouse PG classification
NA
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