| Gene Information | |
|---|---|
| Gene Name | FADS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1) |
| Target Name | fatty acid desaturase 1 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000149485 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O60427 |
| Gene Card | FADS1 |
| Uniprot ID | O60427 |
| Pfam | PF00173; PF00487 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000032122) |
| Ortholog in Animals | Alpaca_ FADS1 ( ortholog_one2one ) Dog_ FADS1 ( ortholog_one2one ) GuineaPig_ FADS1 ( ortholog_one2one ) Macaque_ FADS1 ( ortholog_one2one ) Mouse_ Fads1 ( ortholog_one2one ) Pig_ FADS1 ( ortholog_one2one ) Rat_ Fads1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FADS3, FADS2, FADS6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain. {ECO:0000269|PubMed:10601301, ECO:0000269|PubMed:10769175, ECO:0000269|PubMed:10860662}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17856235 |
| Subcellular location [CC] | [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}. Mitochondrion {ECO:0000269|PubMed:22619218}.; [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |