| Gene Information | |
|---|---|
| Gene Name | FAC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 3046 |
| Protein Names | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | NA |
| Gene Card | BPTF |
| Uniprot ID | Q12830 |
| Pfam | PF00439; PF02791; PF00628; PF15613 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level). {ECO:0000269|PubMed:10662542, ECO:0000269|PubMed:10727212, ECO:0000269|PubMed:7621746, ECO:0000269|PubMed:9225734}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.084968(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2F6J (X-ray 2.00A ) 2F6N (X-ray 2.00A ) 2FSA (X-ray 1.90A ) 2FUI (NMR - ) 2FUU (NMR - ) 2RI7 (X-ray 1.45A ) 3QZS (X-ray 1.80A ) 3QZT (X-ray 1.50A ) 3QZV (X-ray 2.00A ) 3UV2 (X-ray 1.58A ) 5H6Y (X-ray 2.00A ) 5R4G (X-ray 1.25A ) 5R4H (X-ray 1.18A ) 5R4I (X-ray 1.28A ) 5R4J (X-ray 1.39A ) 5R4K (X-ray 1.17A ) 5R4L (X-ray 1.13A ) 5R4M (X-ray 1.11A ) 5R4N (X-ray 1.28A ) 5R4O (X-ray 1.05A ) 6AZE (X-ray 2.45A ) 6LU5 (X-ray 1.87A ) 6LU6 (X-ray 1.97A ) 7DMY (X-ray 2.00A ) 7DN4 (X-ray 2.84A ) 7JT4 (X-ray 2.06A ) 7K6R (X-ray 1.60A ) 7K6S (X-ray 1.23A ) 7KDW (X-ray 1.71A ) 7KDZ (X-ray 1.54A ) 7LP0 (X-ray 1.66A ) 7LPK (X-ray 1.39A ) 7LRK (X-ray 1.44A ) 7LRO (X-ray 1.45A ) 7M2E (X-ray 1.75A ) 7RWN (X-ray 1.39A ) 7RWO (X-ray 1.58A ) 7RWP (X-ray 1.73A ) 7RWQ (X-ray 1.90A ) 8AG2 (X-ray 1.02A ) |
| DBSNP | rs1425998598 rs782736894 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques. |
| Mouse PG classification | NA |
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