| Gene Information | |
|---|---|
| Gene Name | FABP6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 128 |
| Protein Names | Gastrotropin (GT) (Fatty acid-binding protein 6) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) (Intestinal bile acid-binding protein) (I-BABP) |
| Target Name | gastrotropin |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000170231 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51161 |
| Gene Card | FABP6 |
| Uniprot ID | P51161 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.307975199) |
| Ortholog in Animals | Alpaca_ FABP6 ( ortholog_one2one ) Dog_ FABP6 ( ortholog_one2one ) GuineaPig_ FABP6 ( ortholog_one2one ) Macaque_ FABP6 ( ortholog_one2one ) Mouse_ Fabp6 ( ortholog_one2one ) Pig_ FABP6 ( ortholog_one2one ) Rat_ Fabp6 ( ortholog_one2one ) Rabbit_ FABP6 ( ortholog_one2one ) |
| Ohnologs | FABP1 |
| Paralogs | CRABP1, FABP9, FABP5, FABP12, RBP1, FABP4, PMP2, RBP2, RBP5, RBP7, FABP3, FABP2, FABP7, FABP1, CRABP2 |
| Tissue | small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). {ECO:0000269|PubMed:17909007, ECO:0000269|PubMed:7588781, ECO:0000269|PubMed:7619861}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1O1U (NMR - ) 1O1V (NMR - ) 2MM3 (NMR - ) 5L8I (X-ray 1.88A ) 5L8N (X-ray 2.12A ) 5L8O (X-ray 2.39A ) |
| DBSNP | rs17856662 rs17852045 rs1130435 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:P80020}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P50119}; Cytoplasmic side {ECO:0000250|UniProtKB:P50119}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17909007}. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells. {ECO:0000269|PubMed:17909007}. |
| Mouse PG classification | NA |
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