| Gene Information | |
|---|---|
| Gene Name | CD209 |
| Organism | Homo sapiens (Human) |
| Gene Length | 404 |
| Protein Names | CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 93 ( ENSG00000090659 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NNX6 |
| Gene Card | CD209 |
| Uniprot ID | Q9NNX6 |
| Pfam | PF00059 |
| In ASD | yes |
| Allosteric Prediction | yes (0.046788289) |
| Ortholog in Animals | Alpaca_ CD209 ( ortholog_one2one ) Macaque_ CD209 ( ortholog_one2one ) Mouse_ Cd209b ( ortholog_one2many ) Mouse_ Cd209c ( ortholog_one2many ) Mouse_ Cd209a ( ortholog_one2many ) Mouse_ Cd209e ( ortholog_one2many ) Mouse_ Cd209d ( ortholog_one2many ) Rat_ RGD1564571 ( ortholog_one2many ) Rat_ Cd209a ( ortholog_one2many ) Rat_ Cd209e ( ortholog_one2many ) Rat_ Cd209 ( ortholog_one2many ) Rat_ Clec4m ( ortholog_one2many ) Rat_ Cd209c ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | ASGR1, CLEC4G, CLEC4C, CLEC4M, CLEC17A, ASGR2, CLEC4A, CLEC4F, CLEC10A, CLEC6A, FCER2, CLEC4D, CD207, CLEC4E |
| Tissue | adipose.tissue, ovary |
| Tissue Specificity | Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. {ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:11337487}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1K9I (X-ray 2.50A ) 1SL4 (X-ray 1.55A ) 1SL5 (X-ray 1.80A ) 2B6B (EM 25.00A ) 2IT5 (X-ray 2.40A ) 2IT6 (X-ray 1.95A ) 2XR5 (X-ray 1.42A ) 2XR6 (X-ray 1.35A ) 6GHV (X-ray 2.10A ) 7NL6 (X-ray 2.20A ) 7NL7 (X-ray 2.10A ) |
| DBSNP | rs1003686123 rs11465377 rs11465380 rs11465393 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; [Isoform 5]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; [Isoform 6]: Secreted {ECO:0000305}.; [Isoform 7]: Secreted {ECO:0000305}.; [Isoform 8]: Secreted {ECO:0000305}.; [Isoform 9]: Secreted {ECO:0000305}.; [Isoform 10]: Secreted {ECO:0000305}.; [Isoform 11]: Secreted {ECO:0000305}.; [Isoform 12]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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