| Gene Information | |
|---|---|
| Gene Name | SYNE4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 404 |
| Protein Names | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000181392 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8N205 |
| Gene Card | SYNE4 |
| Uniprot ID | Q8N205 |
| Pfam | PF10541 |
| In ASD | no |
| Allosteric Prediction | no (-1.42266982) |
| Ortholog in Animals | Alpaca_ SYNE4 ( ortholog_one2one ) Dog_ ALKBH6 ( ortholog_one2one ) GuineaPig_ SYNE4 ( ortholog_one2one ) Macaque_ SYNE4 ( ortholog_one2one ) Mouse_ Syne4 ( ortholog_one2one ) Pig_ SYNE4 ( ortholog_one2one ) Rat_ Syne4 ( ortholog_one2one ) Rabbit_ SYNE4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | cerebellar.hemisphere, cerebellum, minor.salivary.gland, pituitary.gland, prostate, thyroid |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6R16 (X-ray 2.75A ) 6WMD (X-ray 1.50A ) |
| DBSNP | rs34818970 rs2285422 |
| Subcellular location [CC] | Nucleus outer membrane {ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer membrane requires the presence of SUN1. {ECO:0000250}. |
| Mouse PG classification | NA |
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