| Gene Information | |
|---|---|
| Gene Name | FAAH |
| Organism | Homo sapiens (Human) |
| Gene Length | 372 |
| Protein Names | Fatty acid 2-hydroxylase (EC 1.14.18.-) (Fatty acid alpha-hydroxylase) (Fatty acid hydroxylase domain-containing protein 1) |
| Target Name | fatty-acid amide hydrolase 1 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000117480 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q7L5A8 |
| Gene Card | FA2H |
| Uniprot ID | Q7L5A8 |
| Pfam | PF00173; PF04116 |
| In ASD | no |
| Allosteric Prediction | yes (0.464016115) |
| Ortholog in Animals | Alpaca_ FAAH ( ortholog_one2one ) Dog_ FAAH ( ortholog_one2one ) GuineaPig_ FAAH ( ortholog_one2one ) Macaque_ FAAH ( ortholog_one2one ) Mouse_ Faah ( ortholog_one2one ) Pig_ FAAH ( ortholog_one2one ) Rat_ Faah ( ortholog_one2one ) Rabbit_ FAAH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FAAH2, QRSL1 |
| Tissue | NA |
| Tissue Specificity | Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes (PubMed:17355976). Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney (PubMed:15337768). {ECO:0000269|PubMed:15337768, ECO:0000269|PubMed:17355976}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs121918217 rs35874850 rs387907040 rs387907039 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5MPP0}; Multi-pass membrane protein {ECO:0000269|PubMed:15337768}. Microsome membrane {ECO:0000269|PubMed:15337768}; Multi-pass membrane protein {ECO:0000269|PubMed:15337768}. |
| Mouse PG classification | NA |
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