Gene Information
Gene NameF9
OrganismHomo sapiens (Human)
Gene Length461
Protein NamesCoagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
Target Namecoagulation factor ix
Target TypeNA
Gene Age950 ( ENSG00000101981 )
Evolutionary StageEukaryota
AlphaFoldDBP00740
Gene CardF9
Uniprot IDP00740
PfamPF00008; PF00594; PF00089
In ASDyes
Allosteric Predictionyes (1.000034925)
Ortholog in AnimalsAlpaca_ F9 ( ortholog_one2one )
Dog_ F9 ( ortholog_one2one )
GuineaPig_ F9 ( ortholog_one2one )
Macaque_ F9 ( ortholog_one2one )
Mouse_ F9 ( ortholog_one2one )
Pig_ F9 ( ortholog_one2one )
Rat_ F9 ( ortholog_one2one )
Rabbit_ F9 ( ortholog_one2one )
OhnologsF10
ParalogsHGFAC, F7, C1R, KLK10, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11
Tissueliver
Tissue SpecificityDetected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma. {ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:3857619}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.1(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CFH  (NMR  1CFI  (NMR  1EDM  (X-ray  1.50A  1IXA  (NMR  1MGX  (NMR  1NL0  (X-ray  2.20A  1RFN  (X-ray  2.80A  2WPH  (X-ray  1.50A  2WPI  (X-ray  1.99A  2WPJ  (X-ray  1.60A  2WPK  (X-ray  2.21A  2WPL  (X-ray  1.82A  2WPM  (X-ray  2.00A  3KCG  (X-ray  1.70A  3LC3  (X-ray  1.90A  3LC5  (X-ray  2.62A  4WM0  (X-ray  2.37A  4WMA  (X-ray  1.62A  4WMB  (X-ray  2.05A  4WMI  (X-ray  1.87A  4WMK  (X-ray  2.08A  4WN2  (X-ray  1.95A  4WNH  (X-ray  1.95A  4YZU  (X-ray  1.41A  4Z0K  (X-ray  1.41A  4ZAE  (X-ray  1.86A  5EGM  (X-ray  1.84A  5F84  (X-ray  2.50A  5F85  (X-ray  2.15A  5F86  (X-ray  1.90A  5JB8  (X-ray  1.45A  5JB9  (X-ray  1.30A  5JBA  (X-ray  1.40A  5JBB  (X-ray  1.56A  5JBC  (X-ray  1.90A  5TNO  (X-ray  1.54A  5TNT  (X-ray  1.40A  5VYG  (X-ray  2.20A  6MV4  (X-ray  1.37A  6RFK  (X-ray  1.60A  6X5J  (X-ray  2.51A  6X5L  (X-ray  2.25A  6X5P  (X-ray  2.00A  7AHV  (X-ray  3.11A 
DBSNP rs150190385  rs387906481  rs367569299  rs1327097914  rs1275708479  rs1275708479  rs1603264205  rs1410080079  rs137852225  rs137852226  rs137852228  rs137852229  rs137852230  rs137852231  rs1603264719  rs137852233  rs137852274  rs1603264727  rs1603265481  rs1216516070  rs1330705989  rs137852237  rs137852238  rs6048  rs137852241  rs137852240  rs137852242  rs137852243  rs137852243  rs1182648920  rs267606792  rs1603267181  rs137852246  rs137852247  rs137852279  rs137852249  rs137852251  rs1222227572  rs137852254  rs137852275  rs137852257  rs137852258  rs137852259  rs1303221289  rs137852283  rs1175050951  rs1175050951  rs137852273  rs137852281  rs137852278  rs137852277  rs137852276  rs1233706534  rs1306658513  rs137852265  rs137852280  rs1928129466  rs1170838100  rs767828752  rs1385141619  rs137852266  rs1603267474  rs137852267  rs137852268  rs143018900  rs757996262  rs1243180674  rs137852269  rs1603267486  rs4149751 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:3857619, ECO:0000269|PubMed:8295821, ECO:0000269|PubMed:9169594}.
Mouse PG classificationHPG
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