Gene Information | |
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Gene Name | F9 |
Organism | Homo sapiens (Human) |
Gene Length | 461 |
Protein Names | Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain] |
Target Name | coagulation factor ix |
Target Type | NA |
Gene Age | 950 ( ENSG00000101981 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | P00740 |
Gene Card | F9 |
Uniprot ID | P00740 |
Pfam | PF00008; PF00594; PF00089 |
In ASD | yes |
Allosteric Prediction | yes (1.000034925) |
Ortholog in Animals | Alpaca_ F9 ( ortholog_one2one ) Dog_ F9 ( ortholog_one2one ) GuineaPig_ F9 ( ortholog_one2one ) Macaque_ F9 ( ortholog_one2one ) Mouse_ F9 ( ortholog_one2one ) Pig_ F9 ( ortholog_one2one ) Rat_ F9 ( ortholog_one2one ) Rabbit_ F9 ( ortholog_one2one ) |
Ohnologs | F10 |
Paralogs | HGFAC, F7, C1R, KLK10, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11 |
Tissue | liver |
Tissue Specificity | Detected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma. {ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:3857619}. |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.1(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 1CFH (NMR - ) 1CFI (NMR - ) 1EDM (X-ray 1.50A ) 1IXA (NMR - ) 1MGX (NMR - ) 1NL0 (X-ray 2.20A ) 1RFN (X-ray 2.80A ) 2WPH (X-ray 1.50A ) 2WPI (X-ray 1.99A ) 2WPJ (X-ray 1.60A ) 2WPK (X-ray 2.21A ) 2WPL (X-ray 1.82A ) 2WPM (X-ray 2.00A ) 3KCG (X-ray 1.70A ) 3LC3 (X-ray 1.90A ) 3LC5 (X-ray 2.62A ) 4WM0 (X-ray 2.37A ) 4WMA (X-ray 1.62A ) 4WMB (X-ray 2.05A ) 4WMI (X-ray 1.87A ) 4WMK (X-ray 2.08A ) 4WN2 (X-ray 1.95A ) 4WNH (X-ray 1.95A ) 4YZU (X-ray 1.41A ) 4Z0K (X-ray 1.41A ) 4ZAE (X-ray 1.86A ) 5EGM (X-ray 1.84A ) 5F84 (X-ray 2.50A ) 5F85 (X-ray 2.15A ) 5F86 (X-ray 1.90A ) 5JB8 (X-ray 1.45A ) 5JB9 (X-ray 1.30A ) 5JBA (X-ray 1.40A ) 5JBB (X-ray 1.56A ) 5JBC (X-ray 1.90A ) 5TNO (X-ray 1.54A ) 5TNT (X-ray 1.40A ) 5VYG (X-ray 2.20A ) 6MV4 (X-ray 1.37A ) 6RFK (X-ray 1.60A ) 6X5J (X-ray 2.51A ) 6X5L (X-ray 2.25A ) 6X5P (X-ray 2.00A ) 7AHV (X-ray 3.11A ) |
DBSNP | rs150190385 rs387906481 rs367569299 rs1327097914 rs1275708479 rs1275708479 rs1603264205 rs1410080079 rs137852225 rs137852226 rs137852228 rs137852229 rs137852230 rs137852231 rs1603264719 rs137852233 rs137852274 rs1603264727 rs1603265481 rs1216516070 rs1330705989 rs137852237 rs137852238 rs6048 rs137852241 rs137852240 rs137852242 rs137852243 rs137852243 rs1182648920 rs267606792 rs1603267181 rs137852246 rs137852247 rs137852279 rs137852249 rs137852251 rs1222227572 rs137852254 rs137852275 rs137852257 rs137852258 rs137852259 rs1303221289 rs137852283 rs1175050951 rs1175050951 rs137852273 rs137852281 rs137852278 rs137852277 rs137852276 rs1233706534 rs1306658513 rs137852265 rs137852280 rs1928129466 rs1170838100 rs767828752 rs1385141619 rs137852266 rs1603267474 rs137852267 rs137852268 rs143018900 rs757996262 rs1243180674 rs137852269 rs1603267486 rs4149751 |
Subcellular location [CC] | Secreted {ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:3857619, ECO:0000269|PubMed:8295821, ECO:0000269|PubMed:9169594}. |
Mouse PG classification | HPG |
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