Gene Information
Gene NameF8
OrganismHomo sapiens (Human)
Gene Length2351
Protein NamesCoagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]
Target Namecoagulation factor viii
Target TypeSuccessful target
Gene Age544 ( ENSG00000185010 )
Evolutionary StageVertebrata
AlphaFoldDBP00451
Gene CardF8
Uniprot IDP00451
PfamPF00394; PF07731; PF07732; PF00754
In ASDno
Allosteric Predictionyes (0.53219604)
Ortholog in AnimalsAlpaca_ F8 ( ortholog_one2one )
Dog_ F8 ( ortholog_one2one )
GuineaPig_ F8 ( ortholog_one2one )
Macaque_ F8 ( ortholog_one2one )
Mouse_ F8 ( ortholog_one2one )
Pig_ F8 ( ortholog_one2one )
Rat_ F8 ( ortholog_one2one )
Rabbit_ F8 ( ortholog_one2one )
OhnologsNA
ParalogsCNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1
TissueNA
Tissue SpecificityNA
Pharmacological Animal Models0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CFG  (NMR  -  )  1D7P  (X-ray  1.50A  )  1FAC  (NMR  -  )  1IQD  (X-ray  2.00A  )  2R7E  (X-ray  3.70A  )  3CDZ  (X-ray  3.98A  )  3HNB  (X-ray  1.15A  )  3HNY  (X-ray  1.07A  )  3HOB  (X-ray  2.07A  )  3J2Q  (EM  15.00A  )  3J2S  (EM  15.00A  )  4BDV  (X-ray  3.98A  )  4KI5  (X-ray  2.47A  )  4PT6  (X-ray  2.10A  )  4XZU  (X-ray  2.61A  )  5K8D  (X-ray  4.19A  )  6MF0  (X-ray  3.20A  )  6MF2  (X-ray  3.61A  )  7K66  (X-ray  3.92A  )  7KBT  (X-ray  4.15A  )  7KWO  (EM  2.90A  ) 
DBSNP rs137852377  rs137852378  rs137852476  rs137852379  rs1261929809  rs944567323  rs1800288  rs781974394  rs1218133483  rs137852380  rs137852381  rs1296842178  rs137852382  rs1312347909  rs137852383  rs137852384  rs137852385  rs782481755  rs137852386  rs137852387  rs137852388  rs137852389  rs137852390  rs137852391  rs1388356765  rs1433420305  rs1281943689  rs137852392  rs137852392  rs137852393  rs1455943875  rs137852394  rs137852395  rs137852367  rs1341730743  rs137852475  rs1603436218  rs1603436217  rs137852396  rs137852397  rs1464962436  rs137852398  rs1208703993  rs34371500  rs137852399  rs137852400  rs137852359  rs868988809  rs137852401  rs137852402  rs1401805753  rs137852403  rs137852403  rs137852404  rs137852405  rs137852406  rs137852407  rs1603435395  rs781954986  rs1189348665  rs137852371  rs137852370  rs137852410  rs375241473  rs137852364  rs28935499  rs28933668  rs28933669  rs28933670  rs28933671  rs1234456704  rs28933672  rs1258333672  rs1362305882  rs1362305882  rs1441830456  rs28937272  rs111033616  rs1603435217  rs1304348198  rs1240470740  rs1240470740  rs1345538633  rs782485864  rs1603435026  rs137852412  rs137852411  rs137852413  rs137852414  rs35383156  rs1269117966  rs139526001  rs137852415  rs137852416  rs137852417  rs137852417  rs137852418  rs137852419  rs137852420  rs782193428  rs28937282  rs782657516  rs137852422  rs1354815715  rs137852376  rs137852423  rs1460318222  rs1299810903  rs137852424  rs137852425  rs137852426  rs137852427  rs1253524555  rs137852428  rs137852429  rs1557280438  rs137852430  rs137852431  rs137852433  rs137852434  rs1603434460  rs1569559755  rs1384374956  rs137852435  rs1218576358  rs1305924233  rs137852436  rs1485277601  rs28937285  rs2228152  rs782318401  rs28933673  rs1800291  rs1800292  rs1800294  rs782127226  rs28935203  rs111033613  rs111033614  rs137852439  rs137852373  rs137852362  rs151202877  rs137852440  rs137852441  rs28937287  rs28937289  rs1168919288  rs1466581271  rs137852375  rs1263565590  rs137852443  rs137852443  rs137852442  rs137852444  rs137852445  rs28933674  rs28933675  rs28933676  rs28933677  rs28933678  rs28933678  rs28933679  rs1290383918  rs28933680  rs1416920499  rs28933681  rs1160914716  rs1364158178  rs137852369  rs28933682  rs28937294  rs28937294  rs111033615  rs1273080258  rs137852450  rs137852451  rs1490417405  rs1367630608  rs1343859825  rs1190563629  rs137852453  rs1406262850  rs1320622042  rs1603432908  rs369414658  rs1603432906  rs137852454  rs137852455  rs1348849974  rs1569559494  rs137852456  rs137852457  rs1603432783  rs1267586059  rs1475665992  rs137852458  rs137852459  rs137852366  rs137852460  rs1603431562  rs1321311878  rs1450770782  rs782641941  rs137852461  rs137852462  rs137852463  rs137852464  rs137852465  rs137852465  rs137852467  rs137852466  rs1405473814  rs781797728  rs137852365  rs782098979  rs137852468  rs782548763  rs1229477261  rs137852355  rs137852358  rs137852358  rs1603431508  rs782654096  rs137852469  rs782479558  rs782479558  rs1800297  rs137852470  rs782717799  rs1603430929  rs137852472  rs137852374  rs137852473  rs137852473  rs137852474  rs137852360  rs137852360  rs137852360  rs1557271042 
Subcellular location [CC]Secreted, extracellular space.
Mouse PG classificationLPG
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