| Gene Information | |
|---|---|
| Gene Name | PLCB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1216 |
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000182621 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NQ66 |
| Gene Card | PLCB1 |
| Uniprot ID | Q9NQ66 |
| Pfam | PF06631; PF09279; PF17787; PF00388; PF00387; PF08703 |
| In ASD | no |
| Allosteric Prediction | yes (1.176792082) |
| Ortholog in Animals | Alpaca_ PLCB1 ( ortholog_one2one ) Dog_ PLCB1 ( ortholog_one2one ) GuineaPig_ PLCB1 ( ortholog_one2one ) Macaque_ PLCB1 ( ortholog_one2one ) Mouse_ Plcb1 ( ortholog_one2one ) Pig_ PLCB1 ( ortholog_one2one ) Rat_ Plcb1 ( ortholog_one2one ) Rabbit_ PLCB1 ( ortholog_one2one ) |
| Ohnologs | PLCB2, PLCB3 |
| Paralogs | PLCG2, PLCD3, PLCB3, PLCE1, PLCG1, PLCD4, PLCD1, PLCB2, PLCB4, PLCL2, PLCH1, PLCL1, PLCZ1, PLCH2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1227346164 |
| Subcellular location [CC] | Nucleus membrane {ECO:0000250|UniProtKB:Q9Z1B3}. Cytoplasm {ECO:0000250|UniProtKB:P10687}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:Q9Z1B3}. |
| Mouse PG classification | NA |
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