| Gene Information | |
|---|---|
| Gene Name | F2RL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 385 |
| Protein Names | Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3) |
| Target Name | proteinase activated receptor 4 |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000127533 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96RI0 |
| Gene Card | F2RL3 |
| Uniprot ID | Q96RI0 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.140968381) |
| Ortholog in Animals | Alpaca_ F2RL3 ( ortholog_one2one ) Dog_ F2RL3 ( ortholog_one2one ) GuineaPig_ F2RL3 ( ortholog_one2one ) Macaque_ F2RL3 ( ortholog_one2one ) Mouse_ F2rl3 ( ortholog_one2one ) Pig_ F2RL3 ( ortholog_one2one ) Rat_ F2rl3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | F2RL2, F2RL1, F2R, P2RY8, GPR20, LPAR4, LPAR6, P2RY10, GPR35, GPR55, GPR18, GPR65, CYSLTR2, GPR17, GPR4, CYSLTR1 |
| Tissue | lung |
| Tissue Specificity | Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2ZPK (X-ray 1.80A ) 3QDZ (X-ray 2.80A ) |
| DBSNP | rs773902 rs2230799 rs2227346 rs2227376 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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