| Gene Information | |
|---|---|
| Gene Name | F2R |
| Organism | Homo sapiens (Human) |
| Gene Length | 425 |
| Protein Names | Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor) |
| Target Name | proteinase activated receptor 1 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000181104 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P25116 |
| Gene Card | F2R |
| Uniprot ID | P25116 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.744410115) |
| Ortholog in Animals | Alpaca_ F2R ( ortholog_one2one ) Dog_ F2R ( ortholog_one2one ) GuineaPig_ F2R ( ortholog_one2one ) Macaque_ F2R ( ortholog_one2one ) Mouse_ F2r ( ortholog_one2one ) Pig_ F2R ( ortholog_one2one ) Rat_ F2r ( ortholog_one2one ) Rabbit_ F2R ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | F2RL1, F2RL2, F2RL3, P2RY8, GPR20, LPAR4, LPAR6, P2RY10, GPR35, GPR55, GPR18, GPR65, CYSLTR2, GPR17, GPR4, CYSLTR1 |
| Tissue | NA |
| Tissue Specificity | Platelets and vascular endothelial cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NRN (X-ray 3.10A ) 1NRO (X-ray 3.10A ) 1NRP (X-ray 3.00A ) 1NRQ (X-ray 3.50A ) 1NRR (X-ray 2.40A ) 3BEF (X-ray 2.20A ) 3HKI (X-ray 2.20A ) 3HKJ (X-ray 2.60A ) 3LU9 (X-ray 1.80A ) 3VW7 (X-ray 2.20A ) |
| DBSNP | rs5893 rs2230849 rs2227832 rs1055103 rs17849599 rs2227799 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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